Glucagon (1-29), bovine, human, porcine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Glucagon (1-29), bovine, human, porcine 是由胰腺 α 细胞产生的一种多肽激素。Glucagon 促进糖异生。Glucagon (1-29), bovine, human, porcine 可激活 HNF4α 并促进 HNF4α 磷酸化。

Glucagon (1-29), bovine, human, porcine is a peptide hormone, produced by pancreatic α-cells. Glucagon stimulates gluconeogenesis. Glucagon (1-29), bovine, human, porcine activates HNF4α and increases HNF4α phosphorylation.

Western Blot Analysis Cell Line:Human primary hepatocytes (H1211, HH1215) Concentration:100 nM Incubation Time:Result:Resulted in a marked increase in the amount of phosphorylated HNF4α.

Animal Model:C57BL/6J mice (12- to 24-week-old) Dosage:20 μg/kg and 1 mg/kg Administration:Administered by i.p. injection; 45 minutes Result:Low-dose (20 μg/kg) increased glycemia and did not stimulate insulin secretion.High-dose (1 mg/kg) lowered glycemia and stimulated insulin secretion.

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Others

Other Targets

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16941-32-5

3482.75

C153H225N43O49S

>98% (HPLC)

In Vitro:?H2O 中的溶解度 : 6.67 mg/mL (1.92 mM; 超声助溶 酸性条件溶解 (HCL 调节，pH≈3))DMSO 中的溶解度 : 2 mg/mL (0.57 mM; 超声助溶 吸湿的 DMSO 对产品的溶解度有显著影响）

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(-20℃)

With Ice Pack

≥ 2 years